The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy.

@article{Lin2010TheNA,
  title={The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy.},
  author={Yong Lin and Lang Bai and Wenjie Chen and Shanling Xu},
  journal={Expert opinion on therapeutic targets},
  year={2010},
  volume={14 1},
  pages={
          45-55
        }
}
IMPORTANCE OF THE FIELD Nuclear factor kappa B (NF-kappaB) is activated by a variety of cancer-promoting agents. The reciprocal activation between NF-kappaB and inflammatory cytokines makes NF-kappaB important for inflammation-associated cancer development. Both the constitutive and anticancer therapeutic-induced NF-kappaB activation blunts the anticancer activities of the therapy. Elucidating the roles of NF-kappaB in cancer facilitates developing approaches for cancer prevention and therapy… CONTINUE READING
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