• Medicine
  • Published in
    The Journal of biological…
    2000

The NF-kappa B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death.

@article{RiveraWalsh2000TheNB,
  title={The NF-kappa B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death.},
  author={Isis Rivera-Walsh and Mary Ellen Cvijic and Gu Xiao and Shao Cong Sun},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 33},
  pages={
          25222-30
        }
}
Stimulation of T cells by antigens or mitogens triggers multiple signaling pathways leading to activation of genes encoding interleukin-2 and other growth-regulatory cytokines. The same stimuli also activate the gene encoding an apoptosis-inducing molecule, Fas ligand (FasL), which contributes to activation-induced cell death. It has been proposed that the signaling pathways involved in cytokine gene induction also contribute to activation-induced FasL expression; however, genetic evidence for… CONTINUE READING

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