The NF-kappa B-inducing kinase induces PC12 cell differentiation and prevents apoptosis.

@article{Foehr2000TheNB,
  title={The NF-kappa B-inducing kinase induces PC12 cell differentiation and prevents apoptosis.},
  author={Erik D. Foehr and Jan Bohuslav and Liang Chen and Carlos DeNoronha and Romas Geleziunas and Xin Lin and Alison O'Mahony and Warner C. Greene},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 44},
  pages={34021-4}
}
NF-kappa B has been implicated in the survival and differentiation of PC12 cells. In this study, we examined the effect of the NF-kappa B-inducing kinase (NIK) on these processes. When inducibly expressed in PC12 cells, a kinase-proficient but not -deficient form of NIK promoted neurite process formation and mediated anti-apoptotic signaling. As expected, NIK expression led to I kappa B kinase activation and induced nuclear translocation of NF-kappa B. However, NIK-induced neurite outgrowth was… CONTINUE READING