The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles.

@article{Marion2012TheNS,
  title={The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles.},
  author={Sabrina Marion and Julie Mazzolini and Floriane Herit and Pierre Bourdoncle and Nad{\`e}ge Kambou-Pene and Stephan Hailfinger and Martin Sachse and Juergen Ruland and Alexandre Benmerah and Arnaud Echard and M Thome and Florence Niedergang},
  journal={Developmental cell},
  year={2012},
  volume={23 5},
  pages={954-67}
}
The protein Bcl10 contributes to adaptive and innate immunity through the assembly of a signaling complex that plays a key role in antigen receptor and FcR-induced NF-κB activation. Here we demonstrate that Bcl10 has an NF-κB-independent role in actin and membrane remodeling downstream of FcR in human macrophages. Depletion of Bcl10 impaired Rac1 and PI3K activation and led to an abortive phagocytic cup rich in PI(4,5)P(2), Cdc42, and F-actin, which could be rescued with low doses of F-actin… CONTINUE READING
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