The NEF4 complex regulates Rad4 levels and utilizes Snf2/Swi2-related ATPase activity for nucleotide excision repair.

@article{Ramsey2004TheNC,
  title={The NEF4 complex regulates Rad4 levels and utilizes Snf2/Swi2-related ATPase activity for nucleotide excision repair.},
  author={Kerrington L Ramsey and Joshua J Smith and Arindam Dasgupta and Nazif Maqani and Patrick Grant and David T. Auble},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 14},
  pages={6362-78}
}
Nucleotide excision repair factor 4 (NEF4) is required for repair of nontranscribed DNA in Saccharomyces cerevisiae. Rad7 and the Snf2/Swi2-related ATPase Rad16 are NEF4 subunits. We report previously unrecognized similarity between Rad7 and F-box proteins. Rad16 contains a RING domain embedded within its ATPase domain, and the presence of these motifs in NEF4 suggested that NEF4 functions as both an ATPase and an E3 ubiquitin ligase. Mutational analysis provides strong support for this model… CONTINUE READING