The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cells.

@article{Zhao2011TheNE,
  title={The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cells.},
  author={Liqun Zhao and Ping Yue and Sagar Lonial and Fadlo R. Khuri and Shi-yong R Sun},
  journal={Molecular cancer therapeutics},
  year={2011},
  volume={10 12},
  pages={2415-25}
}
TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective cytokine with potential anticancer activity and is currently under clinical testing. Head and neck squamous cell carcinoma (HNSCC), like other cancer types, exhibits varied sensitivity to TRAIL. MLN4924 is a newly developed investigational small molecule inhibitor of NEDD8-activating enzyme with potent anticancer activity. This study reveals a novel function of MLN4924 in synergizing with TRAIL to induce apoptosis in HNSCC cells… CONTINUE READING

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CHOPdependent DR5 induction and ubiquitin/proteasome–mediated c-FLIP Zhao et al. Mol Cancer Ther; 2011 Molecular Cancer Therapeutics

  • S Chen, X Liu, P Yue, AH Schonthal, FR Khuri, SY. Sun
  • OF10 on June
  • 2011
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