The NECAP PHear domain increases clathrin accessory protein binding potential.

Abstract

AP-2 is a key regulator of the endocytic protein machinery driving clathrin-coated vesicle (CCV) formation. One critical function, mediated primarily by the AP-2 alpha-ear, is the recruitment of accessory proteins. NECAPs are alpha-ear-binding proteins that enrich on CCVs. Here, we have solved the structure of the conserved N-terminal region of NECAP 1… (More)

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@article{Ritter2007TheNP, title={The NECAP PHear domain increases clathrin accessory protein binding potential.}, author={Brigitte Ritter and Alexei Yu Denisov and Jacynthe Philie and Patrick D Allaire and Valerie Legendre-Guillemin and Peter Zylbergold and Kalle Gehring and Peter S McPherson}, journal={The EMBO journal}, year={2007}, volume={26 18}, pages={4066-77} }