The NCI-H295 cell line: a pluripotent model for human adrenocortical studies.

@article{Rainey1994TheNC,
  title={The NCI-H295 cell line: a pluripotent model for human adrenocortical studies.},
  author={William E. Rainey and Ian M. Bird and James Ian Mason},
  journal={Molecular and cellular endocrinology},
  year={1994},
  volume={100 1-2},
  pages={45-50}
}
The human adrenal cortex is a complex endocrine organ that secretes mineralocorticoids, glucocorticoids and adrenal androgens. These steroids arise from morphologically and biochemically distinct zones of the adrenal gland. Studying secretion of these distinct steroid hormones has, in the past, required the isolation of cells from each of the adrenocortical zones. Indeed, the lack of a human adrenocortical cell line retaining the ability to produce any of the major adrenal steroid products has… CONTINUE READING