The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion.

@article{Gao2015TheNS,
  title={The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion.},
  author={Shangbang Gao and Lin Xie and Taizo Kawano and Michelle D. Po and Sihui Asuka Guan and Mei Zhen and Jennifer K Pirri and Mark J. Alkema},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={6323}
}
Persistent neural activity, a sustained circuit output that outlasts the stimuli, underlies short-term or working memory, as well as various mental representations. Molecular mechanisms that underlie persistent activity are not well understood. Combining in situ whole-cell patch clamping and quantitative locomotion analyses, we show here that the Caenorhabditis elegans neuromuscular system exhibits persistent rhythmic activity, and such an activity contributes to the sustainability of basal… CONTINUE READING

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