The NALP3 inflammasome is involved in the innate immune response to amyloid-β

@article{Halle2008TheNI,
  title={The NALP3 inflammasome is involved in the innate immune response to amyloid-β},
  author={Annett Halle and V. Hornung and Gabor C Petzold and Cameron R. Stewart and Brian G Monks and Thomas Reinheckel and Katherine A. Fitzgerald and Eicke Latz and Kathryn J. Moore and Douglas T Golenbock},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={857-865}
}
The fibrillar peptide amyloid-β (Aβ) has a chief function in the pathogenesis of Alzheimer's disease. Interleukin 1β (IL-1β) is a key cytokine in the inflammatory response to Aβ. Insoluble materials such as crystals activate the inflammasome formed by the cytoplasmic receptor NALP3, which results in the release of IL-1β. Here we identify the NALP3 inflammasome as a sensor of Aβ in a process involving the phagocytosis of Aβ and subsequent lysosomal damage and release of cathepsin B. Furthermore… CONTINUE READING
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