The NALP3 inflammasome is involved in the innate immune response to amyloid-β

  title={The NALP3 inflammasome is involved in the innate immune response to amyloid-β},
  author={Annett Halle and V. Hornung and Gabor C Petzold and Cameron R. Stewart and Brian G Monks and Thomas Reinheckel and Katherine A. Fitzgerald and Eicke Latz and Kathryn J. Moore and Douglas T Golenbock},
  journal={Nature Immunology},
The fibrillar peptide amyloid-β (Aβ) has a chief function in the pathogenesis of Alzheimer's disease. Interleukin 1β (IL-1β) is a key cytokine in the inflammatory response to Aβ. Insoluble materials such as crystals activate the inflammasome formed by the cytoplasmic receptor NALP3, which results in the release of IL-1β. Here we identify the NALP3 inflammasome as a sensor of Aβ in a process involving the phagocytosis of Aβ and subsequent lysosomal damage and release of cathepsin B. Furthermore… CONTINUE READING
Highly Influential
This paper has highly influenced 47 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 669 extracted citations


Publications referenced by this paper.
Showing 1-10 of 48 references

Similar Papers

Loading similar papers…