The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.

@article{Ueno2005TheNO,
  title={The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.},
  author={Noriko Ueno and Ryu Takeya and Kei Miyano and Hideaki Kikuchi and Hideki Sumimoto},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 24},
  pages={23328-39}
}
Nox3, a member of the superoxide-producing NADPH oxidase (Nox) family, participates in otoconia formation in mouse inner ears, which is required for perception of balance and gravity. The activity of other Nox enzymes such as gp91(phox)/Nox2 and Nox1 is known to absolutely require both an organizer protein (p47(phox) or Noxo1) andanactivatorprotein (p67… CONTINUE READING