• Corpus ID: 31935443

The NAD deficiency diseases.

@article{Cleary1986TheND,
  title={The NAD deficiency diseases.},
  author={John P. Cleary},
  journal={Journal of Orthomolecular Medicine},
  year={1986}
}
  • J. Cleary
  • Published 1986
  • Biology
  • Journal of Orthomolecular Medicine
Vitamin B3 occurs in two forms, nicotinamide and nicotinic acid. They were first isolated from liver in 1937 by Conrad El-vehjem and shown to be what was then called the PP factor or pellagra preventative factor. The name was later changed to vitamin B3, commonly called niacin for the nicotinic acid form and niacinamide for the amide form. Soon after, a synopsis of the early research on the compound was published in 1941 by the Merck Company. The coenzymes NAD and NADP which niacin makes are… 
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References

SHOWING 1-10 OF 47 REFERENCES
RELATIONSHIP BETWEEN NICOTINIC ACID AND A CODEHYDROGENASE (COZYMASE): IN BLOOD OF PELLAGRINS AND NORMAL PERSONS
TLDR
Extensive treatment of several hundred pellagrins with nicotinic acid has shown that B. influenzae can be used to measure accurately the cozymase content of the blood in normal persons and in pellAGrins.
The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra.
TLDR
This preliminary study finds that the existence of therapeutically cross-reacting homologous catalyst and substrate deficiency forms of pellagra are postulated, the first contributing to the B vitamin deficiency epidemics of 50-100 years ago, the second to the more recent endemic "Diseases of Western Civilization" which express in certain genetic subgroups as the major mental illnesses of today.
The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra.
  • D. O. Rudin
  • Medicine, Psychology
    Biological psychiatry
  • 1981
TLDR
This preliminary study finds that the existence of therapeutically cross-reacting homologous catalyst and substrate deficiency forms of pellagra are postulated, the first contributing to the B vitamin deficiency epidemics of 50-100 years ago, the second to the more recent endemic "Diseases of Western Civilization" which express in certain genetic subgroups as the major mental illnesses of today.
AN ALCOHOL DETOXICATION MECHANISM IN THE CENTRAL NERVOUS SYSTEM
TLDR
An alcohol oxidation mechanism has been found to be present in brain and two members of the vitamin B complex, namely nicotinic acid and riboflavin are components, i.
Effect of Yeast and Nicotinic Acid on Porphyrinuria.∗
TLDR
The present study shows that nicotinic acid, a substance which has been shown to be curative for the mucous membrane lesions of pellagra, likewise produces a decrease of porphyrinuria in pellagrins.
Nicotinic Acid in Delirium Tremens
TLDR
It is shown in animal experiments that degenerative processes of the central nervous system from vitamin A deficiency are furthered by excess of carbohydrates; similar factors may play a part in ergotism and lathyrism.
Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic islets
TLDR
It is described that both Streptozotocin and alloxan cause DNA strand breaks which stimulate nuclear poly(ADP–ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
Nicotinamide adenine dinucleotide depresses synaptic transmission in the hippocampus and has specific binding sites on the synaptic membranes
TLDR
It was concluded that NAD probably depressed synaptic transmission in the dentate gyrus by binding to sites on the presynaptic nerve terminal and reducing the amount of transmitter released by a nerve impulse.
The use of nicotinic acid and pyridoxine in the treatment of schizophrenia.
TLDR
The hypothesis that combined administration of nicotinic acid and pyridoxine has greater therapeutic effects than the component drugs in chronic schizophrenic patients was tested but could not be substantiated in a 48-week study.
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