The NAD deficiency diseases.
@article{Cleary1986TheND, title={The NAD deficiency diseases.}, author={John P. Cleary}, journal={Journal of Orthomolecular Medicine}, year={1986} }
Vitamin B3 occurs in two forms, nicotinamide and nicotinic acid. They were first isolated from liver in 1937 by Conrad El-vehjem and shown to be what was then called the PP factor or pellagra preventative factor. The name was later changed to vitamin B3, commonly called niacin for the nicotinic acid form and niacinamide for the amide form. Soon after, a synopsis of the early research on the compound was published in 1941 by the Merck Company. The coenzymes NAD and NADP which niacin makes are…
6 Citations
Antioxidant enzyme levels in red blood cells of chronic alcoholic men patients during oral niacin therapy
- Medicine
- 1990
Oral niacin therapy (Vitamin B3) has given promising results in the treatment of so-called NAD deficiency diseases such as alcohol and opiate addiction.. Niacin as a co-factor of ethanol metabolism…
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It has been proposed that the histadelic patient does not respond to the classical meganutrient (B3, vitamin C) therapy, and this lack of response is confusing considering that thousands of schizophrenic patients have benefited from taking megadoses of vitamins B3 and C.
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Although niacin has numerous therapeutic benefits, it may also result in a considerable number of side effects both acute and chronic, subjective and objective, and there are certain fractions of the general population that may be deficient in niac in, requiring supplementation to prevent pellagra (the disease of niacIn deficiency).
Functional Medicine: The Missing Link in Addictionology
- Philosophy, Medicine
- 2000
&NA; “There is a principle which is a bar against all information, which is proof against all arguments and which cannot fail to keep a [person] in everlasting ignorance—that principle is contempt…
References
SHOWING 1-10 OF 47 REFERENCES
RELATIONSHIP BETWEEN NICOTINIC ACID AND A CODEHYDROGENASE (COZYMASE): IN BLOOD OF PELLAGRINS AND NORMAL PERSONS
- Biology
- 1939
Extensive treatment of several hundred pellagrins with nicotinic acid has shown that B. influenzae can be used to measure accurately the cozymase content of the blood in normal persons and in pellAGrins.
Increase in hepatic NAD level ‐ its effect on the redox state and on ethanol and acetaldehyde metabolism
- MedicineFEBS letters
- 1974
The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra.
- Medicine, Psychology
- 1981
This preliminary study finds that the existence of therapeutically cross-reacting homologous catalyst and substrate deficiency forms of pellagra are postulated, the first contributing to the B vitamin deficiency epidemics of 50-100 years ago, the second to the more recent endemic "Diseases of Western Civilization" which express in certain genetic subgroups as the major mental illnesses of today.
The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra.
- Medicine, PsychologyBiological psychiatry
- 1981
This preliminary study finds that the existence of therapeutically cross-reacting homologous catalyst and substrate deficiency forms of pellagra are postulated, the first contributing to the B vitamin deficiency epidemics of 50-100 years ago, the second to the more recent endemic "Diseases of Western Civilization" which express in certain genetic subgroups as the major mental illnesses of today.
AN ALCOHOL DETOXICATION MECHANISM IN THE CENTRAL NERVOUS SYSTEM
- Medicine
- 1943
An alcohol oxidation mechanism has been found to be present in brain and two members of the vitamin B complex, namely nicotinic acid and riboflavin are components, i.
Effect of Yeast and Nicotinic Acid on Porphyrinuria.∗
- Biology
- 1938
The present study shows that nicotinic acid, a substance which has been shown to be curative for the mucous membrane lesions of pellagra, likewise produces a decrease of porphyrinuria in pellagrins.
Nicotinic Acid in Delirium Tremens
- MedicineBritish medical journal
- 1939
It is shown in animal experiments that degenerative processes of the central nervous system from vitamin A deficiency are furthered by excess of carbohydrates; similar factors may play a part in ergotism and lathyrism.
Streptozotocin and alloxan induce DNA strand breaks and poly(ADP–ribose) synthetase in pancreatic islets
- BiologyNature
- 1981
It is described that both Streptozotocin and alloxan cause DNA strand breaks which stimulate nuclear poly(ADP–ribose) synthetase, thereby depleting intracellular NAD and inhibiting proinsulin synthesis in isolated pancreatic islets of rats.
Nicotinamide adenine dinucleotide depresses synaptic transmission in the hippocampus and has specific binding sites on the synaptic membranes
- BiologyBritish journal of pharmacology
- 1983
It was concluded that NAD probably depressed synaptic transmission in the dentate gyrus by binding to sites on the presynaptic nerve terminal and reducing the amount of transmitter released by a nerve impulse.
The use of nicotinic acid and pyridoxine in the treatment of schizophrenia.
- Psychology, MedicineInternational pharmacopsychiatry
- 1981
The hypothesis that combined administration of nicotinic acid and pyridoxine has greater therapeutic effects than the component drugs in chronic schizophrenic patients was tested but could not be substantiated in a 48-week study.