The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction.

@article{Mahadev2004TheNO,
  title={The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction.},
  author={Kalyankar Mahadev and Hiroyuki Motoshima and Xiangdong Wu and Jean Marie B. Ruddy and Rebecca S. Arnold and Guangjie Cheng and J. David Lambeth and Barry J. Goldstein},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 5},
  pages={1844-54}
}
Insulin stimulation of target cells elicits a burst of H(2)O(2) that enhances tyrosine phosphorylation of the insulin receptor and its cellular substrate proteins as well as distal signaling events in the insulin action cascade. The molecular mechanism coupling the insulin receptor with the cellular oxidant-generating apparatus has not been elucidated. Using reverse transcription-PCR and Northern blot analyses, we found that Nox4, a homolog of gp91phox, the phagocytic NAD(P)H oxidase catalytic… CONTINUE READING
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