The N-terminus of rodent and human MAD1 confers species-specific stringency to spindle assembly checkpoint

@article{Haller2006TheNO,
  title={The N-terminus of rodent and human MAD1 confers species-specific stringency to spindle assembly checkpoint},
  author={Katrin Haller and Karen V. Kibler and Takefumi Kasai and Y-H Chi and J M P{\'e}lopon{\`e}se and Venkat S. R. K. Yedavalli and K-T Jeang},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={2137-2147}
}
The spindle assembly checkpoint (SAC) guards against chromosomal mis-segregation and the emergence of aneuploidy. SAC in higher eukaryotes includes at least 10 proteins including MAD1-3, BUB1-3, and Msp1. A long-standing observation has been that rodent cells are more tolerant of microtubule toxins than primate cells indicating that SAC function is more relaxed in the former than the latter. Here, we report on an unexpected functional difference between the rodent and human MAD1 component of… CONTINUE READING
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