The N-terminus of RPA large subunit and its spatial position are important for the 5′->3′ resection of DNA double-strand breaks


The first step of homology-dependent repair of DNA double-strand breaks (DSBs) is the resection of the 5' strand to generate 3' ss-DNA. Of the two major nucleases responsible for resection, EXO1 has intrinsic 5'->3' directionality, but DNA2 does not. DNA2 acts with RecQ helicases such as the Werner syndrome protein (WRN) and the heterotrimeric eukaryotic ss… (More)
DOI: 10.1093/nar/gkv764


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