The N-terminus of HIV-1 Tat protein is essential for Tat-TAR RNA interaction

@article{Chaloin2004TheNO,
  title={The N-terminus of HIV-1 Tat protein is essential for Tat-TAR RNA interaction},
  author={Olivier Chaloin and J Peter and J{\'e}r{\^o}me Briand and Beno{\^i}t Masquida and Claude Desgranges and St{\'e}phane Muller and Johan Hoebeke},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2004},
  volume={62},
  pages={355-361}
}
Abstract.The human HIV transactivator protein Tat is essential for efficient viral transcription that occurs by a complex mechanism involving interaction of Tat with the TAR RNA element. This interaction appears to require the mediation of a cellular protein, cyclin T1. However, the possibility that Tat and TAR associate in a binary Tat-TAR complex has been little investigated. Using a chemically synthesized active Tat protein, the kinetic and equilibrium parameters of its interaction with TAR… CONTINUE READING

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