The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity.

@article{Eskeland2004TheNO,
  title={The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity.},
  author={Ragnhild Eskeland and Birgit Czermin and Joern Boeke and Tiziana Bonaldi and Joerg Thomas Regula and Axel Imhof},
  journal={Biochemistry},
  year={2004},
  volume={43 12},
  pages={3740-9}
}
In most eukaryotes, the histone methyltransferase SU(VAR)3-9 and its orthologues play a major role in the function of centromeric heterochromatin. Although the methyltransferase domain is required for the formation of a fully functional centromere, mutations within other regions of the gene such as the N-terminus also have a strong impact on its in vivo function. To analyze the contribution of the N-terminus on the methyltransferase activity, we have expressed the full-length Drosophila SU(VAR… CONTINUE READING

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