The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites.

@article{Fung2005TheNR,
  title={The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites.},
  author={Tsz Fung and Cain H. Yam and Randy Yat Choi Poon},
  journal={Cell cycle},
  year={2005},
  volume={4 10},
  pages={1411-20}
}
Cyclin A is destroyed during mitosis by the ubiquitin-proteasome system. Like cyclin B, a destruction box (D-box) motif is required for the destruction of cyclin A. However, cyclin A degradation is more complicated than cyclin B because cyclin A's D-box motif is more extensive and proteolysis involves complex signaling in some organisms. In this study, we found that in addition to the D-box, the region between residues 123-157 also contributed to the ubiquitination and degradation of human… CONTINUE READING