The N-terminal region of tapasin is required to stabilize the MHC class I loading complex.

@article{Bangia1999TheNR,
  title={The N-terminal region of tapasin is required to stabilize the MHC class I loading complex.},
  author={Naveen Bangia and Paul J Lehner and Eric A. Hughes and Mark Surman and Peter Cresswell},
  journal={European journal of immunology},
  year={1999},
  volume={29 6},
  pages={1858-70}
}
Tapasin mediates the binding of MHC class I molecules to the transporter associated with antigen processing (TAP). Deletion mutants of tapasin were used to examine the effect of tapasin on interactions within the MHC class I complex. Binding to TAP is mediated by the C-terminal region of tapasin. Michaelis-Menten analysis of peptide transport shows that this interaction is sufficient to increase TAP levels without significantly affecting the intrinsic translocation rate. Weak interactions exist… CONTINUE READING

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