The N-terminal region of severe acute respiratory syndrome coronavirus protein 6 induces membrane rearrangement and enhances virus replication.

@article{Zhou2010TheNR,
  title={The N-terminal region of severe acute respiratory syndrome coronavirus protein 6 induces membrane rearrangement and enhances virus replication.},
  author={Haixia Zhou and Debra M Ferraro and Jincun Zhao and Snawar Hussain and Jianqiang Shao and Jonathan Trujillo and Jason M. Netland and Thomas Gallagher and Stanley Perlman},
  journal={Journal of virology},
  year={2010},
  volume={84 7},
  pages={3542-51}
}
The severe acute respiratory syndrome coronavirus (SARS-CoV) accessory protein 6 (p6) is a 63-amino-acid multifunctional Golgi-endoplasmic reticulum (ER) membrane-associated protein, with roles in enhancing virus replication and in evading the innate immune response to infection by inhibiting STAT1 (signal transducer and activator of transcription factor 1) translocation to the nucleus. Here, we demonstrate that p6 has an N-terminal region-cytoplasm-C-terminal region-cytoplasm configuration… CONTINUE READING
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