The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake.

@article{Poppelreuther2012TheNR,
  title={The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake.},
  author={Margarete Poppelreuther and Berenice Mareen Rudolph and Chen Xia Du and Regina Gro{\ss}mann and Melanie Becker and Christoph Thiele and Robert Ehehalt and Joachim Fuellekrug},
  journal={Journal of lipid research},
  year={2012},
  volume={53 5},
  pages={
          888-900
        }
}
Cytosolic lipid droplets (LDs) are storage organelles for neutral lipids derived from endogenous metabolism. Acyl-CoA synthetase family proteins are essential enzymes in this biosynthetic pathway, contributing activated fatty acids. Fluorescence microscopy showed that ACSL3 is localized to the endoplasmic reticulum (ER) and LDs, with the distribution dependent on the cell type and the supply of fatty acids. The N-terminus of ACSL3 was necessary and sufficient for targeting reporter proteins… CONTINUE READING

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