The N-terminal half-domain of the long form of tRNase Z is required for the RNase 65 activity.

@article{Takaku2004TheNH,
  title={The N-terminal half-domain of the long form of tRNase Z is required for the RNase 65 activity.},
  author={Hiroaki Takaku and Asako Minagawa and Masamichi Takagi and Masayuki Nashimoto},
  journal={Nucleic acids research},
  year={2004},
  volume={32 15},
  pages={4429-38}
}
Transfer RNA (tRNA) 3' processing endoribonuclease (tRNase Z) is an enzyme responsible for the removal of a 3' trailer from pre-tRNA. There exists two types of tRNase Z: one is a short form (tRNase ZS) that consists of 300-400 amino acids, and the other is a long form (tRNase ZL) that contains 800-900 amino acids. Here we investigated whether the short and long forms have different preferences for various RNA substrates. We examined three recombinant tRNase ZSs from human, Escherichia coli and… CONTINUE READING