The N-terminal domain of the human eIF2beta subunit and the CK2 phosphorylation sites are required for its function.

@article{Llorens2006TheND,
  title={The N-terminal domain of the human eIF2beta subunit and the CK2 phosphorylation sites are required for its function.},
  author={Franc Llorens and Anna Duarri and Eduard Sarr{\'o} and Nerea Roher and Maria Plana and Emilio Itarte},
  journal={The Biochemical journal},
  year={2006},
  volume={394 Pt 1},
  pages={227-36}
}
CK2 (protein kinase CK2) is known to phosphorylate eIF2 (eukaryotic translation initiation factor 2) in vitro; however, its implication in this process in living cells has remained to be confirmed. The combined use of chemical inhibitors (emodin and apigenin) of CK2 together with transfection experiments with the wild-type of the K68A kinase-dead mutant form of CK2alpha evidenced the direct involvement of this protein kinase in eIF2beta phosphorylation in cultured HeLa cells. Transfection of… CONTINUE READING

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