The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels.

@article{Kiselyov1999TheND,
  title={The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels.},
  author={Kirill I Kiselyov and Gregory A. Mignery and Michael Xi Zhu and Shmuel Muallem},
  journal={Molecular cell},
  year={1999},
  volume={4 3},
  pages={423-9}
}
In the present work, we studied the interaction and effect of several IP3 receptor (IP3R) constructs on the gating of the store-operated (SOC) hTrp3 channel. Full-length IP3R coupled to silent hTrp3 channels in intact cells but did not activate them until stores were depleted of Ca2+. By contrast, constructs containing the IP3-binding domain activated silent hTrp3 channels in unstimulated cells and restored gating of hTrp3 by IP3 in excised plasma membrane patches. We conclude that the N… CONTINUE READING
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