The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties

@article{Bertolotti1999TheND,
  title={The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties},
  author={Anne Bertolotti and Brendan Bell and L{\'a}szl{\'o} Tora},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={8000-8010}
}
In Ewing tumor, the (11;22) chromosomal translocation produces a chimeric molecule composed of the amino-terminal domain of EWS fused to the carboxyl-terminal DNA-binding domain of FLI-1. Previously, we have identified a novel protein TAFII68, which is highly similar to EWS and another closely related protein TLS (also called FUS). We demonstrate that the N-terminus of TAFII68 efficiently stimulates transcription when fused to two different DNA binding domains and that overexpression of TAFII68… CONTINUE READING

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