The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity.

@article{Zhou2003TheND,
  title={The N-terminal domain of APJ, a CNS-based coreceptor for HIV-1, is essential for its receptor function and coreceptor activity.},
  author={Naiming Zhou and Xiaoling Zhang and Xuejun Fan and Elias G. Argyris and Jianhua Fang and Edward Acheampong and G C Dubois and Roger J. Pomerantz},
  journal={Virology},
  year={2003},
  volume={317 1},
  pages={84-94}
}
The human APJ, a G protein-coupled seven-transmembrane receptor, has been found to be dramatically expressed in the human central nervous system (CNS) and also to serve as a coreceptor for the entry of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV). Studies with animal models suggested that APJ and its natural ligand, apelin, play an important role in the central control of body fluid homeostasis, and in regulation of blood pressure and cardiac contractility… CONTINUE READING

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