The N-terminal cytoplasmic domain of neuregulin 1 type III is intrinsically disordered

  title={The N-terminal cytoplasmic domain of neuregulin 1 type III is intrinsically disordered},
  author={Maryna Chukhlieb and Arne Raasakka and Salla Ruskamo and Petri Kursula},
  journal={Amino Acids},
Axonally expressed neuregulin 1 (NRG1) type III is a transmembrane protein involved in various neurodevelopmental processes, including myelination and Schwann cell migration. NRG1 type III has one transmembrane domain and a C-terminal extracellular segment, which contains an epidermal growth factor homology domain. Little is known, however, about the intracellular N terminus of NRG1 type III, and the structure–function relationships of this cytoplasmic domain have remained uncharacterized. In… CONTINUE READING
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