The N-terminal and C-terminal domains of a receptor tyrosine phosphatase are associated by non-covalent linkage.

@article{Yu1992TheNA,
  title={The N-terminal and C-terminal domains of a receptor tyrosine phosphatase are associated by non-covalent linkage.},
  author={Qian-sheng Yu and T Lenardo and Robert A Weinberg},
  journal={Oncogene},
  year={1992},
  volume={7 6},
  pages={1051-7}
}
We have cloned the rat homolog of the human leukocyte common antigen-related gene (LAR), which encodes a transmembrane receptor phosphotyrosine phosphatase, and raised antibodies against its protein product. We present evidence here for a processing event resulting in a two-chain structure of the mature receptor on the cell surface. The LAR protein is synthesized as a 190-kDa precursor which is subsequently cleaved into 145-kDa and 85-kDa fragments. The 145-kDa fragment, representing the amino… CONTINUE READING

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