The N-terminal A domain of fibronectin-binding proteins A and B promotes adhesion of Staphylococcus aureus to elastin.

@article{Roche2004TheNA,
  title={The N-terminal A domain of fibronectin-binding proteins A and B promotes adhesion of Staphylococcus aureus to elastin.},
  author={Fiona M Roche and Robert Downer and Fiona M. Keane and Pietro Speziale and Pyong Woo Park and T. J. Foster},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 37},
  pages={38433-40}
}
The ability of Staphylococcus aureus to adhere to components of the extracellular matrix is an important mechanism for colonization of host tissues during infection. We have previously shown that S. aureus binds elastin, a major component of the extracellular matrix. The integral membrane protein, elastin-binding protein (EbpS), binds soluble elastin peptides and tropoelastin via its surface-exposed N-terminal domain. In this study, we demonstrate that some strains of S. aureus adhere strongly… CONTINUE READING
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