The N-oxidation of trimethylamine in a Jordanian population.

  title={The N-oxidation of trimethylamine in a Jordanian population.},
  author={H F Hadidi and Suzanne Cholerton and Shannon Atkinson and Yacoub M. Irshaid and N. M. Rawashdeh and Jeffrey R Idle},
  journal={British journal of clinical pharmacology},
  volume={39 2},
The ability to oxidise trimethylamine (TMA) to trimethylamine N-oxide (TMAO) is distributed polymorphically within a British white population with the majority of individuals excreting greater than 90% of total urinary TMA as TMAO. The opposite extreme is characterised by a rare inborn error of TMA N-oxidation known as the fish-odour syndrome. However there is a lack of information regarding inter-individual variability in the N-oxidation of TMA in other ethnic groups. In this study the urinary… CONTINUE READING
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