The N-methyl-d-aspartic acid receptor antagonist memantine ameliorates and delays the development of arthritis by enhancing regulatory T cells.

@article{Lindblad2012TheNA,
  title={The N-methyl-d-aspartic acid receptor antagonist memantine ameliorates and delays the development of arthritis by enhancing regulatory T cells.},
  author={Sofia S. Lindblad and Piotr Mydel and Annelie Hellvard and Ing-Marie Jonsson and Maria Bokarewa},
  journal={Neuro-Signals},
  year={2012},
  volume={20 2},
  pages={61-71}
}
The neuroendocrine impact on rheumatoid arthritis is not yet fully described although numerous neurotransmitters are shown to act as inflammatory modulators. One of these is the excitatory transmitter glutamate (Glu). In this study, the influence of the Glu receptor (GluR)-mediated effects on collagen-induced arthritis (CIA) was investigated. CIA was induced in DBA/1 mice by immunization with chicken collagen type II (CII). Mice were exposed to the following GluR antagonists: group 1, the N… CONTINUE READING