The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias

@article{Ellison1995TheNA,
  title={The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias},
  author={G. Ellison},
  journal={Brain Research Reviews},
  year={1995},
  volume={20},
  pages={250-267}
}
  • G. Ellison
  • Published 1995
  • Biology, Medicine
  • Brain Research Reviews
  • Phencyclidine (PCP) and ketamine can induce a model psychosis in drug addicts and exacerbate the symptoms of chronic schizophrenics. The model psychoses these drugs induce mimic a variety of schizophrenic symptoms, including flattened affect, dissociative thought disorder, depersonalization and catatonic states. These symptoms can persist for prolonged periods and chronic PCP and ketamine addicts have persisting memory deficits. Dizocilpine (MK-801) is a simpler drug than PCP or ketamine in its… CONTINUE READING
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