The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias
@article{Ellison1995TheNA, title={The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias}, author={Gaylord D. Ellison}, journal={Brain Research Reviews}, year={1995}, volume={20}, pages={250-267} }
283 Citations
Acute N-methyl-d-aspartate receptor hypofunction induced by MK801 evokes sex-specific changes in behaviors observed in open-field testing in adult male and proestrus female rats
- Psychology, BiologyNeuroscience
- 2013
NMDA Antagonist-Induced Neurotoxicity and Psychosis
- Psychology, Medicine
- 2002
It became apparent that this class of drugs possessed the ability to produce both positive and negative symptoms of schizophrenia, which made NMDA antagonists a more complete animal model than dopamine agonists, the only other class of psychotomimetic drugs that induce only the positive Symptoms of schizophrenia.
Long-term changes in brain following continuous phencyclidine administration: an autoradiographic study using flunitrazepam, ketanserin, mazindol, quinuclidinyl benzilate, piperidyl-3,4-3H(N)-TCP, and AMPA receptor ligands.
- Biology, PsychologyPharmacology & toxicology
- 1999
Autoradiographic studies using a variety of receptor ligands indicated enduring alterations in a number of receptors: these included decreased piperidyl-3,4-3H(N)-TCP (TCP), flunitrazepam, and mazindol binding in many of the limbic regions in which degeneration has been reported previously.
Repeated administration of phencyclidine, amphetamine and MK-801 selectively impairs spatial learning in mice: a possible model of psychotomimetic drug-induced cognitive deficits
- Psychology, BiologyBehavioural pharmacology
- 2003
Five days of repeated PCP, AMPH or MK-801 administration selectively and differentially impaired the ability of mice to discriminate a spatial change, while leaving intact the ability to react to a non-spatial change, thus indicating that these regimens could also mimic some of the cognitive deficits observed in schizophrenia.
Behavioral effects of chronic phencyclidine in monkeys.
- Psychology, BiologyNeuroreport
- 1999
The results indicate that behavioral effects of chronic PCP in primates differ from those seen following acute treatments and represent an appropriate model system for new antipsychotic drug development.
Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine.
- Biology, PsychologyEuropean journal of pharmacology
- 2001
Chronic ketamine use and psychotic symptomatology
- Psychology
- 2008
This thesis examines the effects of chronic use of ketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, on subjective experience and cognition. It is important to explore the…
Microinfusion of the non-competitive N-methyl-d-aspartate receptor antagonist MK-801 (dizocilpine) into the dorsal hippocampus of Wistar rats does not affect latent inhibition and prepulse inhibition, but increases startle reaction and locomotor activity
- Biology, PsychologyNeuroscience
- 2000
Effects on rat thalamic proteome by acute and subchronic MK-801-treatment.
- PsychologyEuropean journal of pharmacology
- 2004
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