The N-methyl-D-aspartate receptor inhibitory potencies of aromatic inhaled drugs of abuse: evidence for modulation by cation-pi interactions.

@article{Raines2004TheNR,
  title={The N-methyl-D-aspartate receptor inhibitory potencies of aromatic inhaled drugs of abuse: evidence for modulation by cation-pi interactions.},
  author={Douglas E. Raines and Fredrick Gioia and Robert J Claycomb and Renna J N Stevens},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2004},
  volume={311 1},
  pages={14-21}
}
Benzene and several close structural analogs are inhaled drugs of abuse with general anesthetic activity. By virtue of their pi electron clouds, they may engage in attractive electrostatic interactions with cationic atomic charges on protein targets. In this study, we tested the hypothesis that inhaled drugs of abuse inhibit human N-methyl-D-aspartate (NMDA) receptors with potencies that correlate with their abilities to engage in cation-pi interactions. Electrophysiological techniques were… CONTINUE READING