The N-end rule pathway of protein degradation.

  title={The N-end rule pathway of protein degradation.},
  author={Alexander Varshavsky},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  volume={2 1},
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. Ubiquitin is a 76-residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of… CONTINUE READING

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