The N-end rule pathway is a sensor of heme.

  title={The N-end rule pathway is a sensor of heme.},
  author={Rong-Gui Hu and Haiqing Wang and Zanxian Xia and Alexander Varshavsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 1},
The conjugation of arginine, by arginyl-transferase, to N-terminal aspartate, glutamate or oxidized cysteine is a part of the N-end rule pathway of protein degradation. We report that arginyl-transferase of either the mouse or the yeast Saccharomyces cerevisiae is inhibited by hemin (Fe(3+)-heme). Furthermore, we show that hemin inhibits arginyl-transferase through a redox mechanism that involves the formation of disulfide between the enzyme's Cys-71 and Cys-72 residues. Remarkably, hemin also… CONTINUE READING


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The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism

T Tenev, M Ditzel, A Zacharios, P Meier
Cell Death Diff • 2007

Arginyl-transferase, its specificity, putative substrates, bidirectional promoter, and splicing-derived isoforms

Hu R-G
J Biol Chem • 2006

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