The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development.

@article{Graciet2009TheNR,
  title={The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development.},
  author={Emmanuelle Graciet and Franziska Walter and Diarmuid S {\'O}'Maoil{\'e}idigh and Stephan Pollmann and Elliot M. Meyerowitz and Alexander Varshavsky and Frank Wellmer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 32},
  pages={13618-23}
}
The ubiquitin-dependent N-end rule pathway relates the in vivo half-life of a protein to the identity of its N-terminal residue. This proteolytic system is present in all organisms examined and has been shown to have a multitude of functions in animals and fungi. In plants, however, the functional understanding of the N-end rule pathway is only beginning. The N-end rule has a hierarchic structure. Destabilizing activity of N-terminal Asp, Glu, and (oxidized) Cys requires their conjugation to… CONTINUE READING

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The N-end rule pathway is a sensor of heme.

Proceedings of the National Academy of Sciences of the United States of America • 2008

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