The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α

@inproceedings{Hu2007TheNT,
  title={The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α},
  author={Cheng-Jun Hu and Aneesa Sataur and Liyi Wang and Hongqing Chen and Marie Celeste Simon},
  year={2007}
}
The basic helix-loop-helix-Per-ARNT-Sim proteins hypoxia-inducible factor (HIF)-1 and HIF-2 are the principal regulators of the hypoxic transcriptional response. Although highly related, they can activate distinct target genes. In this study, the protein domain and molecular mechanism important for HIF target gene specificity are determined. We demonstrate that although HIF-2 is unable to activate multiple endogenous HIF-1‐specific target genes (e.g., glycolytic enzymes), HIF-2 still binds to… CONTINUE READING

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