• Medicine
  • Published 1961

The N-Hydroxylation of 4-Acetylaminobiphenyl by the Rat and Dog and the Strong Carcinogenicity of N-Hydroxy-4-acetylaminobiphenyl in the Rat

@inproceedings{Miller1961TheNO,
  title={The N-Hydroxylation of 4-Acetylaminobiphenyl by the Rat and Dog and the Strong Carcinogenicity of N-Hydroxy-4-acetylaminobiphenyl in the Rat},
  author={James A. Miller and Carole S. Wyatt and Elizabeth Carolyn Miller and Henrik A. Hartmann},
  year={1961}
}
Summary N -Hydroxy-4-acetylaminobiphenyl has been identified as a urinary metabolite of the carcinogens 4-acetylaminobiphenyl and 4-aminobiphenyl in the rat. 4-Acetylaminobiphenyl, but not 4-aminobiphenyl, yielded the same metabolite in the dog. The N -hydroxy metabolite was excreted as a conjugate which was easily cleaved by a bacterial β-glucuronidase preparation but not by Takadiastase. The identity of the metabolic N -hydroxy-4-acetylaminobiphenyl was established by its isolation in… CONTINUE READING

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