The N‐end rule pathway of protein degradation

@article{Varshavsky1997TheNR,
  title={The N‐end rule pathway of protein degradation},
  author={A. Varshavsky},
  journal={Genes to Cells},
  year={1997},
  volume={2}
}
The N‐end rule relates the in vivo half‐life of a protein to the identity of its N‐terminal residue. Similar but distinct versions of the N‐end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N‐end rule pathway is a part of the ubiquitin system. Ubiquitin is a 76‐residue protein whose covalent conjugation to other proteins plays a role in many biological processes, including cell growth and differentiation. I discuss the current understanding of… Expand
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