The N‐Acylethanolamine‐Hydrolyzing Acid Amidase (NAAA)

@article{Tsuboi2007TheNA,
  title={The N‐Acylethanolamine‐Hydrolyzing Acid Amidase (NAAA)},
  author={K. Tsuboi and N. Takezaki and N. Ueda},
  journal={Chemistry & Biodiversity},
  year={2007},
  volume={4}
}
Bioactive N‐acylethanolamines, including the endocannabinoid anandamide and anti‐inflammatory N‐palmitoylethanolamine, are hydrolyzed to fatty acids and ethanolamine in animal tissues by the catalysis of fatty acid amide hydrolase (FAAH). We recently cloned cDNA of N‐acylethanolamine‐hydrolyzing acid amidase (NAAA), another enzyme catalyzing the same reaction, from human, rat, and mouse. NAAA reveals no sequence homology with FAAH and belongs to the choloylglycine hydrolase family. The most… Expand
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