The N‐Acylethanolamine‐Hydrolyzing Acid Amidase (NAAA)

@article{Tsuboi2007TheNA,
  title={The N‐Acylethanolamine‐Hydrolyzing Acid Amidase (NAAA)},
  author={Kazuhito Tsuboi and Naoko Takezaki and Natsuo Ueda},
  journal={Chemistry \& Biodiversity},
  year={2007},
  volume={4}
}
Bioactive N‐acylethanolamines, including the endocannabinoid anandamide and anti‐inflammatory N‐palmitoylethanolamine, are hydrolyzed to fatty acids and ethanolamine in animal tissues by the catalysis of fatty acid amide hydrolase (FAAH). We recently cloned cDNA of N‐acylethanolamine‐hydrolyzing acid amidase (NAAA), another enzyme catalyzing the same reaction, from human, rat, and mouse. NAAA reveals no sequence homology with FAAH and belongs to the choloylglycine hydrolase family. The most… 
N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA).
Expression and secretion of N-acylethanolamine-hydrolysing acid amidase in human prostate cancer cells.
TLDR
The results showed that both the enzymes were functionally active and found that NAAA was partly secreted from LNCaP cells, which underlined possible usefulness of this enzyme as a biomarker of prostate cancer.
Enzymological studies on the biosynthesis of N-acylethanolamines.
Activity-Based Probe for N-Acylethanolamine Acid Amidase.
TLDR
A derivative of ARN726 is designed and validated as the first activity-based protein profiling (ABPP) probe for the in vivo detection of NAAA and is a useful new tool to identify activated NAAA both in vitro and in vivo and to investigate the physiological and pathological roles of this enzyme.
Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols
TLDR
Overall, NC, ACER3, and, to a lesser extent, NAAA hydrolyze fluorogenic RBM14 compounds with different selectivity, but none of them was specific for a particular enzyme.
Title Activity-Based Probe for N-Acylethanolamine Acid Amidase Permalink
TLDR
A derivative of ARN726 is designed and validated as the first activity-based protein profiling (ABPP) probe for the in vivo detection of NAAA and is a useful new tool to identify activated NAAA both in vitro and in vivo and to investigate the physiological and pathological roles of this enzyme.
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
TLDR
The results suggest that PEA activation of PPAR-α in leukocytes serves as an early stop signal that contrasts the progress of inflammation, and the PEA-hydrolyzing amidase NAAA may provide a previously undescribed target for antiinflammatory medicines.
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TLDR
Comb complementary DNA cloning and functional expression of the enzyme termed “N-acylethanolamine-hydrolyzing acid amidase (NAAA)” from human, rat, and mouse demonstrated that NAAA is a novel N-acyleddylamine-Hydrolyzed enzyme that shows structural and functional similarity to acid ceramidase.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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