The Myxoma Poxvirus Protein, M11L, Prevents Apoptosis by Direct Interaction with the Mitochondrial Permeability Transition Pore

@article{Everett2002TheMP,
  title={The Myxoma Poxvirus Protein, M11L, Prevents Apoptosis by Direct Interaction with the Mitochondrial Permeability Transition Pore},
  author={Helen Everett and Michele Barry and Xuejun Sun and Siow Fong Lee and Christine Frantz and Luc G{\'e}rard Berthiaume and Grant Mcfadden and Robert Chris Bleackley},
  journal={The Journal of Experimental Medicine},
  year={2002},
  volume={196},
  pages={1127 - 1140}
}
M11L, an antiapoptotic protein essential for the virulence of the myxoma poxvirus, is targeted to mitochondria and prevents the loss of mitochondrial membrane potential that accompanies cell death. In this study we show, using a cross-linking approach, that M11L physically associates with the mitochondrial peripheral benzodiazepine receptor (PBR) component of the permeability transition (PT) pore. Close association of M11L and the PBR is also indicated by fluorescence resonance energy transfer… CONTINUE READING

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M11L: A novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes

  • H. Everett, M. Barry, +5 authors G. McFadden
  • J. Exp. Med
  • 2000
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