The Mystery of the Plate: Fleming's Discovery and Contribution to the Early Development of Penicillin

@article{Wainwright1993TheMO,
  title={The Mystery of the Plate: Fleming's Discovery and Contribution to the Early Development of Penicillin},
  author={Milton Wainwright},
  journal={Journal of Medical Biography},
  year={1993},
  volume={1},
  pages={59 - 65}
}
  • M. Wainwright
  • Published 1 February 1993
  • Biology, Medicine
  • Journal of Medical Biography
The Moment: In the late summer of 1928 Alexander Heming (Figure 1) was unexpectedly called back to St Mary's Hospital from his holiday home in Suffolk. While passing time in his laboratory he casually glanced at some petri dishes that had been left on the bench. Suddenly he exclaimed "That's funny", and at that moment he had made what would prove to be one of the most important discoveries in the history of medicine Heming had discovered penicillin, the first and most important of the true… Expand
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References

SHOWING 1-10 OF 15 REFERENCES
Besredka's "antivirus" in relation to Fleming's initial views on the nature of penicillin.
TLDR
Fleming's thoughts on the nature of penicillin were markedly altered by Besredka's "antivirus", as well as anecdotal evidence that he persisted with the view that it might one day find a use in medicine. Expand
The history of the therapeutic use of crude penicillin.
The antibacterial properties of culture filtrates of Penicillium notatum were discovered in 1928 by Alexander Fleming,' but the realization of penicillin's full therapeutic potential had to await theExpand
On a Remarkable Bacteriolytic Element Found in Tissues and Secretions
TLDR
A substance present in the tissues and secretions of the body, which is capable of rapidly dissolving certain bacteria, is called a “Lysozyme,” and is alluded to as the Micrococcus lysodeikticus. Expand
Some Properties of a Bacterial-Inhibitory Substance Produced by a Mold
  • R. D. Reid
  • Medicine, Biology
  • Journal of bacteriology
  • 1935
TLDR
In 1929, Fleming observed that a mold which he identified as Penicillium rubrum (Biourge), but which more closely resembles Pencillium notatum (Westling) was able to produce a substance which inhibited the growth of certain bacteria. Expand
C.G. Paine and the earliest surviving clinical records of penicillin therapy.
ImagesFigure 1Figure 2Figure 3
The man and the myth
The Kon-Tiki Man – Thor Heyerdahl.By Christopher Railing. BBC: 1990. Pp.335. £16.95
New light on the history of penicillin.
  • R. Hare
  • Biology, Medicine
  • Medical history
  • 1982
ImagesFigure 1Figure 2Figure 3Figure 4
Fleming's early search for antibiotics other than penicillin
  • Soc Gen Microbiol Quart
  • 1991
Discussion on Penicillin
Action of Penicillin on Enterococci and Other Streptococci
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2
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