The Myeloid U937 Skin Sensitization Test (U-SENS) addresses the activation of dendritic cell event in the adverse outcome pathway for skin sensitization.

@article{Piroird2015TheMU,
  title={The Myeloid U937 Skin Sensitization Test (U-SENS) addresses the activation of dendritic cell event in the adverse outcome pathway for skin sensitization.},
  author={C{\'e}cile Piroird and Jean-Marc Ovigne and Françoise Rousset and Silvia Martinozzi-Teissier and Charles Gomes and Jos{\'e} Cotovio and Nathalie Al{\'e}p{\'e}e},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2015},
  volume={29 5},
  pages={901-16}
}
The U-SENS™ assay, formerly known as MUSST (Myeloid U937 Skin Sensitization Test), is an in vitro method to assess skin sensitization. Dendritic cell activation following exposure to sensitizers was modelled in the U937 human myeloid cell line by measuring the induction of the expression of CD86 by flow cytometry. The predictive performance of U-SENS™ was assessed via a comprehensive comparison analysis with the available human and LLNA data of 175 substances. U-SENS™ showed 79% specificity, 90… CONTINUE READING

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