The Mycobacterium tuberculosis regulatory network and hypoxia

  title={The Mycobacterium tuberculosis regulatory network and hypoxia},
  author={James E. Galagan and Kyle J. Minch and Matthew Peterson and Anna Lyubetskaya and Elham Azizi and Linsday Sweet and Antonio Gomes and Tige R. Rustad and Gregory Dolganov and Irina Glotova and Thomas Abeel and Chris Mahwinney and Adam D. Kennedy and Ren{\'e} Allard and William Brabant and Andrew Krueger and Suma Jaini and Brent Honda and Wen-Han Yu and Mark J. Hickey and Jeremy Zucker and Christopher Garay and Brian Weiner and Peter Sisk and Christian Stolte and Jessica K. Winkler and Yves Van de Peer and Paul Iazzetti and Diogo Camacho and Jonathan M. Dreyfuss and Yang Liu and Anca Dorhoi and Hans-Joachim Mollenkopf and Paul Drogaris and Julie Lamontagne and Yiyong Zhou and Julie Piquenot and Sang Tae Park and Sahadevan Raman and Stefan H. E. Kaufmann and Robert P. Mohney and Daniel Chelsky and D. Branch Moody and David R. Sherman and Gary K. Schoolnik},
We have taken the first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq and combined this reconstruction with system-wide profiling of messenger RNAs, proteins, metabolites and lipids during hypoxia and re-aeration. Adaptations to hypoxia are thought to have a prominent role in M. tuberculosis pathogenesis. Using ChIP-Seq combined with expression data from the induction of the same factors, we have reconstructed a draft regulatory… CONTINUE READING
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