The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesis.

@article{Sirakova2001TheMT,
  title={The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesis.},
  author={Tatiana D. Sirakova and A K Thirumala and Vinod Shanker Dubey and Howard W. Sprecher and Pappachan E. Kolattukudy},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 20},
  pages={16833-9}
}
Multidrug-resistant tuberculosis is a major global health emergency. Cell wall lipids of Mycobacterium tuberculosis can play crucial roles in the pathogenesis. The enzymes involved in their synthesis can be ideal new drug targets against tuberculosis, because many such lipids are unique to this pathogen. A variety of multiple methyl-branched fatty acids are among such unique lipids. We have identified seven genes highly homologous to the mas gene, which is known to be involved in the production… CONTINUE READING