The Mycobacterium tuberculosis high-affinity iron importer, IrtA, contains an FAD-binding domain.


Iron is an essential nutrient not freely available to microorganisms infecting mammals. To overcome iron deficiency, bacteria have evolved various strategies including the synthesis and secretion of high-affinity iron chelators known as siderophores. The siderophores produced and secreted by Mycobacterium tuberculosis, exomycobactins, compete for iron with… (More)
DOI: 10.1128/JB.00223-09


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