The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen‐associated host innate immune responses

@article{Korf2005TheMT,
  title={The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen‐associated host innate immune responses},
  author={J. Korf and A. Stoltz and J. Verschoor and P. De Baetselier and J. Grooten},
  journal={European Journal of Immunology},
  year={2005},
  volume={35}
}
Recognition of conserved pathogen‐associated molecular patterns constitutes a crucial step in the initiation of innate immune responses. We studied the contribution to the host‐pathogen interaction of mycolic acid (MA), a major lipid component of the cell envelope of the macrophage intracellular pathogen Mycobacterium tuberculosis and other mycobacteria. MA administered to the peritoneal cavity or to the airways induced a unique macrophage morphotype, similar to the foamy macrophage derivatives… Expand
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