The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy.

@article{Leistikow2010TheMT,
  title={The Mycobacterium tuberculosis DosR regulon assists in metabolic homeostasis and enables rapid recovery from nonrespiring dormancy.},
  author={Rachel L. Leistikow and Russell A Morton and Iona L. Bartek and Isaac A. Frimpong and Karleen Wagner and Martin I. Voskuil},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 6},
  pages={1662-70}
}
Mycobacterium tuberculosis survives in latently infected individuals, likely in a nonreplicating or dormancy-like state. The M. tuberculosis DosR regulon is a genetic program induced by conditions that inhibit aerobic respiration and prevent bacillus replication. In this study, we used a mutant incapable of DosR regulon induction to investigate the… CONTINUE READING