The Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis

  title={The Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis},
  author={Kumiko Okada and A. Inoue and M. Okada and Y. Murata and S. Kakuta and Takafumi Jigami and S. Kubo and H. Shiraishi and K. Eguchi and M. Motomura and T. Akiyama and Y. Iwakura and O. Higuchi and Y. Yamanashi},
  pages={1802 - 1805}
  • Kumiko Okada, A. Inoue, +11 authors Y. Yamanashi
  • Published 2006
  • Chemistry, Medicine
  • Science
  • The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine. Upon innervation, neural agrin activates MuSK to establish the postsynaptic apparatus, although agrin-independent formation of neuromuscular synapses can also occur experimentally in the absence of neurotransmission. Dok-7, a MuSK-interacting cytoplasmic protein, is essential for MuSK… CONTINUE READING
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