The Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis

@article{Okada2006TheMP,
  title={The Muscle Protein Dok-7 Is Essential for Neuromuscular Synaptogenesis},
  author={Kumiko Okada and Akane Inoue and M. Okada and Y. Murata and S. Kakuta and Takafumi Jigami and Sachiko Kubo and H. Shiraishi and K. Eguchi and M. Motomura and T. Akiyama and Y. Iwakura and O. Higuchi and Y. Yamanashi},
  journal={Science},
  year={2006},
  volume={312},
  pages={1802 - 1805}
}
The formation of the neuromuscular synapse requires muscle-specific receptor kinase (MuSK) to orchestrate postsynaptic differentiation, including the clustering of receptors for the neurotransmitter acetylcholine. Upon innervation, neural agrin activates MuSK to establish the postsynaptic apparatus, although agrin-independent formation of neuromuscular synapses can also occur experimentally in the absence of neurotransmission. Dok-7, a MuSK-interacting cytoplasmic protein, is essential for MuSK… Expand
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  • 78
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  • 60
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  • 519
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2
3
4
5
...

References

SHOWING 1-10 OF 29 REFERENCES
Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice
  • 869
Agrin promotes synaptic differentiation by counteracting an inhibitory effect of neurotransmitter.
  • 198
  • PDF
Agrin Acts via a MuSK Receptor Complex
  • 639
...
1
2
3
...