The Murine cot Proto‐oncogene: Genome Structure and Tissue‐specific Expression

@inproceedings{Ohara1993TheMC,
  title={The Murine cot Proto‐oncogene: Genome Structure and Tissue‐specific Expression},
  author={Reiko Ohara and Jun Miyoshi and Masahiro Aoki and Kumao Toyoshima},
  booktitle={Japanese journal of cancer research : Gann},
  year={1993}
}
We cloned and analyzed the murine cot proto-oncogene and examined its tissue-specific expression in fetal, newborn and adult mice. Genomic cot DNA consists of eight exons, spanning more than 25 kb, and all intron-exon borders are well conserved as compared to the human homolog. Analysis of the full-length cot cDNA revealed that it contained an open reading frame of 1,401 nucleotides, like human cot proto-oncogene. The sequence identity between murine and human cot gene is 84.4% at the… CONTINUE READING